The roll of honor of the tournament was signed by names of great depth. The winner of the first edition, the Spanish Carreno Busta, reached the top of the ATP world rankings. The last editions of the tournament have had the privilege of having the presence of icons of Italian tennis such as Sergio Palmieri and Corrado Barazzutti, together with authentic champions such as Simone Bolelli (Italian champion ex n.36), Marco Cecchinato (best ranking n.16), Marcel Granollers (best ranking n.19), Stefanos Tsitsipas, Lorenzo Musetti, Pablo Andujar (ex number 32) and Nicolas Almagro ( former world number 9).
The fifth edition will remain in the memory for its Entry List, much more similar to an ATP 250 tournament. Among the champions Albert Ramos-Vinolas, Salvatore Caruso, Damir Dzumhur, Paolo Lorenzi, Thomaz Bellucci (ex n.21), Guillermo Garcia-Lopez (ex n.23) and the winner Federico Delbonis.
The sixth edition, won by the young argentine Tomàs Martin Etcheverry, saw among the young talents Dominic Stricker, Holger Rune, Flavio Cobolli, Giulio Zeppieri, Timofey Skatov.
In 2022, now in its seventh edition, the Internazionali di Tennis Città di Perugia grow in level becoming an ATP Challenger 125. The 2022 Champion is the Spanish tennis player Jaume Munar.